高脱乙酰度低分子量壳聚糖L-乳酸盐的制备工艺研究

论文编号:SP119  论文字数:10574,页数:26

摘要：随着化学及其他化工业的发展及对壳聚糖研究的深入，发现壳聚糖具有许多优异的特性，越来越受到人们的重视。本课题将进行高脱乙酰度低分子量壳聚糖L-乳酸盐的研制，目的是通过提高壳聚糖的脱乙酰度增加壳聚糖游离化铵的浓度，提高其抑菌效果；同时进行L-乳酸化，增加游离化铵的强度，增加其水溶性；而小分子量的壳聚糖也具有良好的水溶性好，容易进入细菌的细胞膜，从而提高其抑菌和杀菌的效果。本文通过使用相转移催化剂来提高壳聚糖的脱乙酰度，使用过氧化氢降解法降低壳聚糖的分子量。高脱乙酰度低分子量壳聚糖L-乳酸盐将具有良好的水溶性和抑菌效果。在眼科用药等领域中具有广阔的前景。
关键词：低聚壳聚糖；高脱乙酰度；相转移催化剂；过氧化氢降解

Abstract：With the developing of chemical industry and in-depth studying of chitosan, people found that chitosan has many excellent characteristics, which attracted more attention. In this topic prepared the chitosan L-lactic acid with high degree and low molecular of deacetylation, Aim to increase the concentration of ammonium by improving the degree of deacetylation Chitosan, and L-lactic acidifying at the same time; increasing the intensity of ammonium to further increase its water-soluble; small molecular Chitosan has good water-solubility, easy accessing to the bacterial cell membrane, thus enhancing its bacteriostatic and bactericidal effects. We used phase transfer catalyst to improve the deacetylation of Chitosan, and the hydrogen peroxide degradation to reduce the molecular of Chitosan. High degree of deacetylation and low molecular Chitosan L-lactate which has good solubility in water has good antibacterial effects. It has broad prospection in the field of ophthalmic medication.

Key  words:  low molecular weight chitosan ;  high deacetylation degree ; Phase transfer catalyst ； hydrogen peroxide depolymerization ;

目录
中文摘要 ............................................................I
英文摘要 ...........................................................II
目录 ..............................................................III
1 绪论 .......................................................................1
1.1 壳聚糖概论 .........................................................1
1.2 低聚壳聚糖的性质和应用 ......................................2
1.3 高脱乙酰度壳聚糖的制备研究进展 ..............................4
1.4 壳低聚塘制备研究进展 ........................................4
1.5脱乙酰度检测方法的研究进展 .................................. 6
2 实验内容 ..........................................................8
2.1实验仪器 .....................................................8
2.2 实验原料与试剂 ..............................................8
2.3 高脱乙酰度的壳聚糖的制备 ....................................8
2.4 壳聚糖脱乙酰度的测定方法 ....................................9
2.5 低分子量壳聚糖的制备........................................10
2.6 壳聚糖溶液分子量的测定方法 .................................11
2.7 低聚壳聚糖L-乳酸盐的制备 ..................................11
3 结果和分析 .......................................................12
3.1 酸碱滴定法与电位滴定法的比较 ...............................12
3.2 各因素对壳聚糖脱乙酰度的影响 ...............................14
3.3 壳聚糖分子量的变化 .........................................16
总结与展望..........................................................20
致谢 ...............................................................21
参考文献 ...........................................................22

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